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Evidence for the presence of tissue factor activity on subendothelium
HJ Weiss, VT Turitto, HR Baumgartner, Y Nemerson and T Hoffmann
Department of Medicine, St Luke's-Roosevelt Hospital Center, New York, NY
10019.
By a variety of methods, tissue factor activity was demonstrated in the
subendothelium of rabbit aorta and human umbilical artery. In one method,
everted segments of de-endothelialized vessels were mounted in an annular
perfusion chamber and the subendothelial surface was exposed to
nonanticoagulated human blood under controlled flow. Procoagulant activity
was assessed by measuring fibrin deposition on subendothelium and
fibrinopeptide A (FPA) levels in post chamber blood. Both fibrin deposition
and FPA were decreased with rabbit vessel segments exposed (at a shear rate
of 650 seconds-1) to blood from patients with factor VII deficiency and
with umbilical artery segments (at shear rates of 90 to 180 seconds-1) that
had been pretreated with a monoclonal antibody to human tissue factor. In a
second method, everted umbilical artery segments were mounted on a stir bar
and the subendothelial surface was exposed, with stirring, to plasma or
purified coagulation factors. The capacity of the surface to clot plasma on
addition of calcium was inhibited by the antibody to tissue factor. The
surface also activated purified 3H-factor X in the presence of factor VIIa,
but not in its absence, and this surface property was almost entirely
eliminated by pretreating the vessel segments with antitissue factor.
Tissue factor activity in subendothelium could play a role in both the
arrest of bleeding and in promoting the formation of thrombi at sites of
vascular injury.
Volume 73,
Issue 4,
pp. 968-975,
03/01/1989
Copyright © 1989 by The American Society of Hematology
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