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Expression of lymphocyte homing receptor as a mechanism of dissemination in
non-Hodgkin's lymphoma
ST Pals, E Horst, GJ Ossekoppele, CG Figdor, RJ Scheper and CJ Meijer
Department of Pathology, Free University, Amsterdam, The Netherlands.
To investigate whether the lymphocyte homing receptor (LHR), an adhesion
molecule believed to play an important role in the control of normal
lymphocyte circulation, influences the spread of non-Hodgkin's lymphoma
(NHL), expression of LHR was examined in 107 NHL of various histologic and
immunophenotypic subclasses. This analysis revealed that whereas NHL with a
putative derivation from recirculating mature T and B lymphocytes almost
invariably express high levels of LHR, those akin to sessile mature or
immature lymphocytes tend to express lower levels of LHR. Furthermore, in a
survey among diffuse large-cell lymphomas of the B-lineage, the tumors of
11 of 13 patients with stage III/IV disease expressed moderate to high
levels of LHR, whereas only two of 17 patients with stage I/II disease had
tumors that did so. These findings suggest that LHR is involved in the
dissemination of NHL.
Volume 73,
Issue 4,
pp. 885-888,
03/01/1989
Copyright © 1989 by The American Society of Hematology
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