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Inhibition of platelet-dependent thrombus formation by human activated
protein C in a primate model
A Gruber, JH Griffin, LA Harker and SR Hanson
Department of Immunology, Research Institute of Scripps Clinic, La Jolla,
CA 92037.
The in vivo antithrombotic properties of human plasma activated protein C
(APC), a natural anticoagulant enzyme, were investigated in a baboon model
of thrombus formation on prosthetic vascular grafts. Infusion of 0.25 to
1.1 mg/kg/h purified, human, APC inhibited blood clotting, as measured by
the activated partial thromboplastin time (APTT), and reduced vascular
graft platelet deposition by 40% to 70%, as determined by the real-time
scintillation camera imaging of 111In-labeled platelet deposition. APC
infusion also preserved graft patency. Hemostatic plug formation remained
normal, as measured by the template bleeding times. These results suggest
that APC administration may produce immediate antithrombotic effects under
arterial flow conditions.
Volume 73,
Issue 3,
pp. 639-642,
02/15/1989
Copyright © 1989 by The American Society of Hematology
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