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Various human hematopoietic growth factors (interleukin-3, GM-CSF, G- CSF)
stimulate clonal growth of nonhematopoietic tumor cells [see comments]
WE Berdel, S Danhauser-Riedl, G Steinhauser and EF Winton
Department of Medicine, Emory University School of Medicine, Atlanta, GA
30322.
We have studied the effect of recombinant human hematopoietic growth
factors (interleukin-3 [rhIL-3], granulocyte-macrophage colony- stimulating
factor [rhGM-CSF], and granulocyte CSF [rhG-CSF]) on the clonal growth of
human colon adenocarcinoma cell lines HTB-38, CCL 187, and WiDr (CCL 218).
The factors stimulated clonal growth of HTB-38 and CCL 187 in a capillary
modification of the human tumor clonogenic assay in agar up to twofold.
There were dose-response correlations over a range of 1 to 10,000 U/mL for
rhIL-3, rhGM-CSF, and rhG-CSF. Incubation with neutralizing monoclonal
antibodies abolished the stimulation of clonal growth by rhGM-CSF. The WiDr
cell line was nonresponsive to rhIL- 3 and rhGM-CSF. These results
represent the first evidence that a variety of hematopoietic growth factors
can stimulate the growth of clonogenic cells of some nonhematopoietic
malignant cell lines in vitro.
Volume 73,
Issue 1,
pp. 80-83,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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