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Alpha-tocopherol, an effective inhibitor of platelet adhesion
J Jandak, M Steiner and PD Richardson
Division of Hematology/Oncology, Brown University, Providence, RI.
Platelet adhesiveness was tested ex vivo in a group of six normal
individuals receiving varying doses of alpha-tocopherol. Adhesion to glass
slides coated with fibronectin, collagen, fibrinogen, or plasma proteins
was studied by perfusing platelet-rich plasma through a flow chamber that
allowed time- and space-resolved observations of platelet adhesion.
Platelet adherence was measured in an area of parallel flow lines and low
shear rate under standardized conditions before and after dietary
supplementation with vitamin E at doses of 200 and 400 IU/d. Platelet
adherence differed in magnitude depending on the adhesive surface. There
was a distinct preference of platelets to adhere to sites that had been
previously occupied. A remarkable decrease in platelet adherence was
observed after vitamin E supplementation. The average decrease in adhesion
after 2 weeks of 200 IU vitamin E was 75%. After 2 weeks of 400 IU vitamin
E, platelet adhesion was reduced by 82%. The inhibitory activity of
alpha-tocopherol was dose dependent and correlated well with the increase
in alpha-tocopherol concentration in platelets after supplementation.
Scanning electron microscopy revealed a striking decrease of pseudopodium
formation in alpha-tocopherol- enriched platelets. Our results suggest that
vitamin E may also be an effective antiadhesive agent in vivo.
Volume 73,
Issue 1,
pp. 141-149,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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