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In situ hybridization histochemistry localization of interleukin-3 mRNA in
mouse brain
WL Farrar, M Vinocour and JM Hill
Laboratory of Molecular Immunoregulation, National Cancer Institute,
Frederick, MD 21701-1013.
The hematopoietic growth factor interleukin-3 (IL-3) promotes the
proliferation and maturation of pluripotent myeloid progenitor cells. In
the immune system, IL-3 is synthesized by mitogen or antigen- stimulated T
lymphocytes. We demonstrate the expression of IL-3 mRNA in mouse brain by
in situ hybridization histochemistry and Northern blot analysis. The IL-3
mRNA is localized in discrete areas of the brain and can be found in
neuronal cell body and astrocytes. Northern analysis of cerebellar RNA,
compared with mRNA extracted from WEHI-3 cells, showed a single
hybridization band, approximately 1.2 kb, suggesting similar processing
between brain and myeloid cells. The molecular evidence and previous
observations of IL-3-like biologic activity found in the brain suggest a
potential role for IL-3 in the neurobiology of the CNS.
Volume 73,
Issue 1,
pp. 137-140,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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