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Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes
during myeloid differentiation
AG Rosmarin, SC Weil, GL Rosner, JD Griffin, MA Arnaout and DG Tenen
Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
During the course of differentiation of early human myeloid cells toward
monocytes and granulocytes, cell surface expression of the cell adhesion
molecule, CD11b/CD18 (Mo1) increases dramatically and expression of
myeloperoxidase (MPO), a bacteriocidal enzyme, decreases markedly. Using
the inducible promyelocytic cell line HL-60 as a model, we studied the mRNA
expression of these genes. Differentiation of these cells along both a
monocytic and a granulocytic pathway demonstrated that the mRNA levels of
the two subunits of CD11b/CD18 increased in a pattern temporally and
quantitatively similar to the increase in cell surface expression of this
heterodimer. In contrast, the expression of MPO mRNA decreased in a
temporal and quantitative pattern similar to the known decrease in MPO
protein during differentiation, suggesting that regulation of these
myeloid-specific proteins may occur at the level of mRNA expression. These
findings have important implications with regard to the nature of the block
in differentiation in acute nonlymphocytic leukemia and the regulation of
myeloid gene expression.
Volume 73,
Issue 1,
pp. 131-136,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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