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Serum granulocyte colony-stimulating factor levels in healthy volunteers
and patients with various disorders as estimated by enzyme immunoassay
K Watari, S Asano, N Shirafuji, H Kodo, K Ozawa, F Takaku and S Kamachi
Department of Hematology-Oncology, Institute of Medical Science, University
of Tokyo, Japan.
In order to better understand the patho-physiologic role of granulocyte
colony-stimulating factor (G-CSF), we estimated its serum levels in healthy
persons and patients with various disorders, using a newly developed enzyme
immunoassay (Motojima et al). In 49 of 56 normal healthy persons (88%), the
levels were beneath the sensitivity of the assay (less than 30 pg/mL),
while in the remaining seven healthy persons, the levels ranged from 33 to
163 pg/mL. On the other hand, nine of 11 patients (82%) with idiopathic
aplastic anemia (AA), one patient with Fanconi's anemia, six of 12 patients
(50%) with myelodysplastic syndrome (MDS), five of 12 patients (42%) with
acute leukemia without any blast cells in the blood (M4: one, M5: one, L1:
one, and L2: two), six of 18 patients (33%) with chronic myeloid leukemia
(CML), one of two patients with chronic lymphoid leukemia (CLL), two of
four patients with lung cancer, one patient with cyclic neutropenia, two of
seven patients with malignant lymphoma, and four patients with acute
infection had G-CSF levels ranging from 46 pg/mL to greater than 2,000
pg/mL. Interestingly, a reverse correlation between blood neutrophil count
and serum G-CSF level was clearly demonstrated for aplastic anemia (r =
-.8169, P less than .01). Moreover, it was found that the G-CSF level rose
during the neutropenic phase of cyclic neutropenia and after chemotherapy
or bone marrow transplantation (BMT) in three patients with leukemia; also
high G-CSF levels were positively correlated to blood neutrophil counts in
some cases of infectious disorders and lung cancer. The cellular sources
and the mechanisms for production and secretion of circulating G-CSF were
not investigated in this study, but the data presented here strongly
indicate that G-CSF plays an important role as a circulating
neutrophilopoietin.
Volume 73,
Issue 1,
pp. 117-122,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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