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In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis
and circulating numbers of RBCs and WBCs
TR Ulich, J del Castillo and KZ Guo
School of Medicine, Department of Pathology, University of California,
Irvine 92717.
Interleukin-6 (IL-6) administered as a single intravenous (IV) injection
caused the following changes in the peripheral circulation of rats: (a) a
biphasic neutrophilia with an initial peak at 1.5 hours and a second
sustained wave of neutrophilia between four and 12 hours, (b) a mild
lymphocytosis at 0.5 hours and a mild lymphopenia between 1.5 and four
hours, and (c) a reticulocytosis between 12 and 24 hours. The bone marrow
showed no significant changes at 1.5 hours, suggesting that the peripheral
neutrophilia at that time is caused by demargination of intravascular
neutrophils and not by release of marrow neutrophils. The bone marrow at 12
hours showed a mild left-shifted myeloid hyperplasia of myeloblasts and
promyelocytes and a tremendous erythroid hyperplasia of intermediate and
late normoblasts. The bone marrow at 24 hours showed a continued mild
myeloid hyperplasia and striking erythroid hyperplasia. In conclusion, IL-6
in vivo acts as a stimulus for myelopoiesis and erythropoiesis and causes
accompanying peripheral changes in the number of neutrophils, lymphocytes,
and RBCs.
Volume 73,
Issue 1,
pp. 108-110,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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