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The human interleukin-1 alpha gene is located on the long arm of chromosome
2 at band q13
M Lafage, N Maroc, P Dubreuil, R de Waal Malefijt, MJ Pebusque, Y Carcassonne and P Mannoni
Department of Hematology and Cell Biology, Regional Cancer Center,
Marseille, France.
Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two
biochemically distinct, but distantly related, polypeptidic cytokines that
play a key role in inflammation, immunologic reactions, and tissue repair.
Recently, it has been shown that IL-1 alpha is identical to hematopoietin
1, which was described as a hematopoietic growth factor acting on early
progenitor cells in synergy with other hematopoietic growth factors. In
this report we discuss our use of in situ hybridization on human
prometaphase cells with a human IL-1 alpha cDNA probe to localize the human
IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at
band q13, in the same chromosomal region as the IL-1 beta gene.
Volume 73,
Issue 1,
pp. 104-107,
01/01/1989
Copyright © 1989 by The American Society of Hematology
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