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K Dorshkind
Division of Biomedical Sciences, University of California, Riverside
92521-0121.
Interleukin-1 (IL-1) has multiple effects on the hematopoietic system. The
present data demonstrate that IL-1 and/or products induced by it reversibly
suppress B-cell differentiation. Upon the addition of 50 U/mL (2.4 ng/mL)
of recombinant IL-1 alpha (rIL-1 alpha) to lymphoid long-term bone marrow
cultures at their initiation, very few B lymphocytes could be detected, and
the majority of cells present were myeloid. This inhibition of B
lymphopoiesis did not appear to be due to effects on proliferation of
mature B cells because IL-1 did not affect the proliferative response of B
cells to form B-cell colonies (CFU-B). The actions of the monokine were
further examined by using myeloid and lymphoid long-term bone marrow
culture systems. The transfer of myeloid long-term bone marrow cultures to
lymphoid conditions usually results in the cessation of myelopoiesis and
initiation of B lymphopoiesis. Exposure of early B-cell precursors present
under the myeloid conditions to 50 U/mL of RIL-1 did not affect their
subsequent differentiation into B cells upon transfer of the cultures to
lymphoid conditions. However, myelopoiesis was sustained, and B
lymphopoiesis did not initiate if 50 U/mL of rIL-1 was added to myeloid
bone marrow cultures at the time of their transfer to the lymphoid
conditions and during biweekly feedings thereafter. Upon removal of IL-1,
myelopoiesis ceased, and B lymphopoiesis initiated. Thus, the effects of
IL-1 on inhibition of B lymphopoiesis are reversible.
This article has been cited by other articles:
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| Copyright © 1988 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
