SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mannucci, P. M. Search for Related Content PubMed PubMed Citation Articles by Mannucci, P. M. Social Bookmarking                   What's this? Next Article  Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders [see comments] PM Mannucci A. Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milano, Italy. Desmopressin (1-deamino-8-D-arginine vasopressin, abbreviated DDAVP) is a synthetic analogue of the antidiuretic hormone L-arginine vasopressin. Because it can raise circulating levels of factor VIII coagulant activity (FVIII) and von Willebrand factor and shorten the prolonged bleeding time, DDAVP is established as a nontransfusional form of treatment for mild and moderate hemophilia and von Willebrand disease. Recently, DDAVP has also been purported to be useful for shortening the prolonged skin bleeding times that occur with uremia, cirrhosis, and platelet dysfunctions of various etiologies. Finally, there is evidence from controlled clinical trials that DDAVP can reduce blood loss and transfusion requirements for hemostatically normal individuals undergoing spinal fusion surgery and for patients undergoing cardiopulmonary bypass surgery. The purpose of this report is to review the therapeutic applications of DDAVP in congenital and acquired bleeding disorders and to discuss areas in which further basic and clinical research is needed. Volume 72, Issue 5, pp. 1449-1455, 11/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. A Doepker, M. R Lucarelli, A. Lehman, and M. B. Shirk Thromboembolic Events During Continuous Vasopressin Infusions: A Retrospective Evaluation Ann. Pharmacother., September 1, 2007; 41(9): 1383 - 1389. [Abstract] [Full Text] [PDF] A. M. Mahdy and N. R. Webster Perioperative systemic haemostatic agents Br. J. Anaesth., December 1, 2004; 93(6): 842 - 858. [Abstract] [Full Text] [PDF] R. A. Reiter, F. Mayr, H. Blazicek, E. Galehr, P. Jilma-Stohlawetz, H. Domanovits, and B. Jilma Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin Blood, December 15, 2003; 102(13): 4594 - 4599. [Abstract] [Full Text] [PDF] W. C. Oliver Jr, P. J. Santrach, G. K. Danielson, G. A. Nuttall, D. R. Schroeder, and M. H. Ereth Desmopressin does not reduce bleeding and transfusion requirements in congenital heart operations Ann. Thorac. Surg., December 1, 2000; 70(6): 1923 - 1930. [Abstract] [Full Text] [PDF] V. J. Martlew Peri-operative management of patients with coagulation disorders Br. J. Anaesth., September 1, 2000; 85(3): 446 - 455. [Abstract] [Full Text] [PDF] G. C. Allen, D. R. Armfield, F. A. Bontempo, L. A. Kingsley, N. A. Goldstein, and J. C. Post Adenotonsillectomy in Children With von Willebrand Disease Arch Otolaryngol Head Neck Surg, May 1, 1999; 125(5): 547 - 551. [Abstract] [Full Text] [PDF] D. Savarese, H. Waitkus, F. M. Stewart, and M. Callery Bloodless Medicine and Surgery J Intensive Care Med, January 1, 1999; 14(1): 20 - 33. [PDF] R. J. Kaufman, A. J. Dorner, and D. N. Fass von Willebrand Factor Elevates Plasma Factor VIII Without Induction of Factor VIII Messenger RNA in the Liver Blood, January 1, 1999; 93(1): 193 - 197. [Abstract] [Full Text] [PDF] J. I. Casas, I. Zuazu-Jausoro, J. Mateo, A. Oliver, H. Litvan, E. Muniz-Diaz, A. Aris, J. M. Caralps, and J. Fontcuberta APROTININ VERSUS DESMOPRESSIN FOR PATIENTS UNDERGOING OPERATIONS WITH CARDIOPULMONARY BYPASS: A double-blind placebo-controlled study J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1107 - 1117. [Abstract] [Full Text] S. Lethagen Desmopressin (DDAVP), tranexamic acid and haemostasis Perfusion, September 1, 1993; 8(5): 417 - 425. [Abstract] [PDF] J. A. Ware and D. D. Heistad Platelet-Endothelium Interactions N. Engl. J. Med., March 4, 1993; 328(9): 628 - 635. [Full Text] P. Grant and P. Wiles The role of 8-arginine vasopressin (antidiuretic hormone) in vascular homeostasis Vascular Medicine, March 1, 1991; 2(1): 85 - 94. [PDF]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020