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Establishment of two Epstein-Barr virus negative Burkitt cell lines from a
patient with AIDS and B-cell lymphoma
A Ganser, C Carlo-Stella, CR Bartram, T Boehm, G Heil, B Henglein, H Muller, A Raghavachar, H von Briesen and F Griesinger
Department of Hematology, University of Frankfurt, FRG.
To analyze the pathogenesis of B-cell lymphomas in patients with acquired
immunodeficiency syndrome (AIDS), we studied two cell lines, Es I and Es
III, established from one such lymphoma for the presence of sequences of
the Epstein-Barr virus (EBV) and the human immunodeficiency virus [HIV;
lymphadenopathy-associated virus (LAV/HTLV- III)] as well as for the
presence of cytogenetic abnormalities and monoclonal rearrangements of
immunoglobulin and T-cell receptor genes. Both cell lines expressed the
same IgM, kappa phenotype as the original lymphoma. The karyotype of Es I
was 46, XY, t(8;14), 2 p+, inv (6p), 17p-, and the cells of Es III had an
additional i(7q). Immunoglobulin gene studies demonstrated the identical
monoclonal rearrangements in both cell lines. Neither EBV nor HIV sequences
were detectable in the malignant B cells at the genomic level, leading to
the conclusion that mechanisms other than transformation by EBV or HIV may
have contributed to the B-cell lymphoma in this patient and possibly also
to the generally increased frequency in patients with AIDS.
Volume 72,
Issue 4,
pp. 1255-1260,
10/01/1988
Copyright © 1988 by The American Society of Hematology
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