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The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]

KI Mills, ED MacKenzie and GD Birnie

Beatson Institute for Cancer Research, Glasgow, Scotland.

The Philadelphia (Ph1) chromosome, characteristic of chronic myelogenous leukemia (CML), arises from a reciprocal translocation between chromosomes 9 and 22. The site of the breakpoint on chromosome 22 is within a small region called the breakpoint cluster region (bcr). We have mapped the breakpoint within the bcr in peripheral blood leukocyte DNA from 22 Ph1-positive CML patients. No correlation between the site of the breakpoint and the clinical phase of the disease was found. However, a striking correlation between the site of the breakpoint and the length of time between presentation and onset of acute phase was observed: on average, patients with a 5' break-point had a fourfold longer chronic phase (median, 203 weeks) than those with a 3' breakpoint (median, 52 weeks).

Volume 72, Issue 4, pp. 1237-1241, 10/01/1988
Copyright © 1988 by The American Society of Hematology


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  Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020