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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blazar, B. R. Articles by Vallera, D. A. Search for Related Content PubMed PubMed Citation Articles by Blazar, B. R. Articles by Vallera, D. A. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony-stimulating factor following transplantation of T-cell-depleted histoincompatible bone marrow BR Blazar, MB Widmer, CC Soderling, S Gillis and DA Vallera Department of Pediatrics, University of Minnesota Hospitals, Minneapolis 55455. In vivo administration of murine recombinant granulocyte/macrophage colony stimulating factor (rGM-CSF) was evaluated for effects on survival and engraftment in an allogeneic murine bone marrow transplantation (BMT) model involving T-cell depletion of donor marrow. The model provides a high incidence of graft failure/rejection. Recipients of continuous subcutaneous infusions of rGM-CSF had a significant survival advantage when compared with untreated controls. However, a significantly lower incidence of donor cell engraftment was noted. Hematological parameters were not substantially affected. When rGM-CSF was administered intraperitoneally (IP), twice daily injections closely approximated the effects of continuous infusion on survival. Single IP injections were without significant effects on survival or engraftment. These results demonstrate that prolonged frequent in vivo exposure to rGM-CSF can significantly improve survival but significantly decreases donor cell repopulation in recipients of T-cell- depleted histoincompatible marrow grafts. Volume 72, Issue 4, pp. 1148-1154, 10/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. van Os, T. M. Sheridan, S. Robinson, D. Drukteinis, J. L.M. Ferrara, and P. M. Mauch Immunogenicity of Ly5 (CD45)-Antigens Hampers Long-Term Engraftment Following Minimal Conditioning in a Murine Bone Marrow Transplantation Model Stem Cells, January 1, 2001; 19(1): 80 - 87. [Abstract] [Full Text]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020