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DDAVP and epinephrine-induced changes in the localization of von Willebrand
factor antigen in endothelial cells of human oral mucosa
M Takeuchi, H Nagura and T Kaneda
Department of Oral Surgery, Nagoya University School of Medicine, Japan.
A peroxidase-labeled antibody technique revealed von Willebrand factor
antigen (vWF:Ag) in rough endoplasmic reticulum (rER), the perinuclear
region, and the cytoplasmic vesicles of capillary endothelial cells in oral
mucosa. After administration of epinephrine or 1-deamino-8-D- arginine
vasopressin (DDAVP), the localization of vWF:Ag was shown to have changed
to the basement membrane and the surrounding interstitium. This change of
vWF:Ag localization induced by epinephrine and DDAVP may play a role in the
adhesion of platelets to subendothelium following endothelial injury during
surgery and may be an unknown hemostatic effect of these drugs.
Volume 72,
Issue 3,
pp. 850-854,
09/01/1988
Copyright © 1988 by The American Society of Hematology
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