|
|
 Previous Article | Table of Contents | Next Article 
Surface antigenic profile and globin phenotype of two new human
erythroleukemia lines: characterization and interpretations
T Papayannopoulou, B Nakamoto, S Kurachi, M Tweeddale and H Messner
Department of Medicine, University of Washington, Seattle 98195.
Detailed characterization of the composite phenotype of two newly
established erythroleukemia lines (OCIM1, OCIM2) shows that these lines
share many of their erythroid markers (ie, surface antigens and globin
program) as well as several of their nonerythroid properties
(myeloid/monocytic/megakaryocytic) with the two known erythroleukemia lines
(K562, HEL). In addition, each displays novel and instructive features. We
argue that the surface and globin phenotype of all erythroleukemia lines is
nonrandom and that it may be of physiologic relevance; it could represent
the most prevalent phenotype of cells transformed by leukemia in vivo, and
it raises the possibility that cells with similar potentials exist
transiently during normal hematopoietic differentiation before their
irreversible commitment to a single lineage. As such, these cells
demonstrate a greater phenotypic adaptability in vitro than do their single
lineage-committed counterparts since they can differentiate toward more
than one lineage.
Volume 72,
Issue 3,
pp. 1029-1038,
09/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Ferrajoli, S. Faderl, Q. Van, P. Koch, D. Harris, Z. Liu, I. Hazan-Halevy, Y. Wang, H. M. Kantarjian, W. Priebe, et al.
WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in Acute Myelogenous Leukemia Cells
Cancer Res.,
December 1, 2007;
67(23):
11291 - 11299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sanchez, I. L. Weissman, M. Pallavicini, M. Valeri, P. Guglielmelli, A. M. Vannucchi, G. Migliaccio, and A. R. Migliaccio
Differential Amplification of Murine Bipotent Megakaryocytic/Erythroid Progenitor and Precursor Cells During Recovery from Acute and Chronic Erythroid Stress
Stem Cells,
February 1, 2006;
24(2):
337 - 348.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Estrov, S. Shishodia, S. Faderl, D. Harris, Q. Van, H. M. Kantarjian, M. Talpaz, and B. B. Aggarwal
Resveratrol blocks interleukin-1{beta}-induced activation of the nuclear transcription factor NF-{kappa}B, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells
Blood,
August 1, 2003;
102(3):
987 - 995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Faderl, D. Harris, Q. Van, H. M. Kantarjian, M. Talpaz, and Z. Estrov
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia
Blood,
July 15, 2003;
102(2):
630 - 637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lepage, M. Leboeuf, J.-P. Cazenave, C. de la Salle, F. Lanza, and G. Uzan
The alpha IIbbeta 3 integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34+ cord blood cells to megakaryocytes
Blood,
December 15, 2000;
96(13):
4169 - 4177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Vannucchi, F. Paoletti, S. Linari, C. Cellai, R. Caporale, P. R. Ferrini, M. Sanchez, G. Migliaccio, and A. R. Migliaccio
Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice
Blood,
April 15, 2000;
95(8):
2559 - 2568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Estrov, S. K. Manna, D. Harris, Q. Van, E. H. Estey, H. M. Kantarjian, M. Talpaz, and B. B. Aggarwal
Phenylarsine Oxide Blocks Interleukin-1beta -Induced Activation of the Nuclear Transcription Factor NF-kappa B, Inhibits Proliferation, and Induces Apoptosis of Acute Myelogenous Leukemia Cells
Blood,
October 15, 1999;
94(8):
2844 - 2853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Cui, M. P. Reilly, S. Surrey, E. Schwartz, and S. E. McKenzie
-245 bp of 5'-Flanking Region From the Human Platelet Factor 4 Gene Is Sufficient to Drive Megakaryocyte-Specific Expression In Vivo
Blood,
April 1, 1998;
91(7):
2326 - 2333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hashimoto and J. Ware
Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibalpha Gene
J. Biol. Chem.,
October 13, 1995;
270(41):
24532 - 24539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Kamel-Reid, M Letarte, C Sirard, M Doedens, T Grunberger, G Fulop, M. Freedman, R. Phillips, and J. Dick
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice
Science,
December 22, 1989;
246(4937):
1597 - 1600.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Ogilvie, X. Yu, V. Nicolas-Metral, S. M. Pulido, C. Liu, U. T. Ruegg, and C. T. Noguchi
Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts
J. Biol. Chem.,
December 8, 2000;
275(50):
39754 - 39761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
