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Clinicopathologic, immunophenotypic, and immunogenotypic analyses of
immunoblastic lymphadenopathy-like T-cell lymphoma
K Tobinai, K Minato, T Ohtsu, K Mukai, Y Kagami, M Miwa, S Watanabe and M Shimoyama
Hematology-Oncology and Clinical Cancer Chemotherapy Division, National
Cancer Center Hospital, Tokyo, Japan.
Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is a distinct
peripheral T-cell lymphoma, which closely resembles angioimmunoblastic
lymphadenopathy with dysproteinemia (AILD) and/or IBL, but is characterized
by focal or sheet-like proliferation of immunoblasts and pale cells of
T-cell nature. In this report, 36 patients with IBL-like T-cell lymphoma
were analyzed. The disease is clinically characterized by generalized lymph
node swelling, hepatosplenomegaly, fever, skin rash, polyclonal
hypergammaglobulinemia, marked male predominance, predilection for the
elderly, and poor prognosis. There was no association with human T-cell
leukemia virus type I or human immunodeficiency virus. IBL-like T-cell
lymphoma may be divided into two categories (CD4+ type and CD8+ type) by
surface marker analysis. It can also be divided into three categories on
the basis of the histologic findings of distribution of morphologically
recognizable tumor cells: nine cases of "inconspicuous type," six cases of
"patchy type," and 21 cases of "diffuse type." Two cases of "inconspicuous
type" converted later to "diffuse type." DNA hybridization analyses in the
ten recent cases revealed that three of four "inconspicuous types" and five
of six "diffuse types" showed clonal rearrangement of T-cell receptor-beta
chain gene without rearrangement of immunoglobulin heavy chain gene,
providing strong evidence for clonal proliferation of T cells.
Volume 72,
Issue 3,
pp. 1000-1006,
09/01/1988
Copyright © 1988 by The American Society of Hematology
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