|
|
 Previous Article | Table of Contents | Next Article 
Autoantibody-associated cross-reactive idiotypes expressed at high
frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of
follicular center cell origin
TJ Kipps, BA Robbins, P Kuster and DA Carson
Department of Basic and Clinical Research, Research Institute of Scripps
Clinic, La Jolla 92037.
Using murine monoclonal antibodies (MoAbs) specific for immunoglobulin (Ig)
cross-reactive idiotypes (CRI), we performed immunohistochemical analyses
on frozen tissue sections and cytocentrifuge preparations of Ig-expressing
malignant cells from patients with chronic lymphocytic leukemia (CLL) and
B-cell non-Hodgkin's lymphomas (NHL) of follicular center cell origin.
Twenty percent (4/20) of the Ig kappa light chain- expressing CLL cells
reacted with 17.109, a MoAb against a major CRI on human IgM autoantibodies
that is encoded by a conserved Ig variable- region gene (V gene) of the V
kappa IIIb sub-subgroup. Another MoAb specific for V kappa IIIb framework
determinant(s) reacted exclusively with all the 17.109-reactive CLL cells.
Only one of 20 kappa light- chain-expressing CLL cells reacted with 6B6.6,
a monoclonal antibody specific for a CRI commonly found on rheumatoid
factor (RF) paraproteins with light-chain variable regions of the V kappa
IIIa sub- subgroup. Finally, greater than 20% (8/34) of all CLL reacted
with G6, a MoAb specific for an Ig heavy chain-associated CRI present on
several RF paraproteins. In contrast, these CRIs were expressed at
significantly lower frequencies in NHL of follicular center cell origin.
Only one of 30 NHL expressing kappa light chains reacted with the 17.109
MoAb. Also, in contrast to the concordance between the 17.109-CRI and V
kappa IIIb framework determinant(s) in CLL, two lymphomas in addition to
the 17.109-reactive lymphoma were recognized by the anti-V kappa IIIb
framework MoAb. None of the NHL reacted with either the 6B6.6 or the G6
MoAbs. These results are the first to demonstrate that CLL and NHL differ
with respect to the expression of autoantibody-associated CRIs. The data
support the notion that NHL of follicular center cell origin differs from
CLL in its utilization and/or somatic mutation of Ig variable-region genes.
The physiological and immunotherapeutic implications of these findings are
discussed.
Volume 72,
Issue 2,
pp. 422-428,
08/01/1988
Copyright © 1988 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. Stamatopoulos, C. Belessi, C. Moreno, M. Boudjograh, G. Guida, T. Smilevska, L. Belhoul, S. Stella, N. Stavroyianni, M. Crespo, et al.
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Blood,
January 1, 2007;
109(1):
259 - 270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Stamatopoulos, C. Belessi, A. Hadzidimitriou, T. Smilevska, E. Kalagiakou, K. Hatzi, N. Stavroyianni, A. Athanasiadou, A. Tsompanakou, T. Papadaki, et al.
Immunoglobulin light chain repertoire in chronic lymphocytic leukemia
Blood,
November 15, 2005;
106(10):
3575 - 3583.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. F. Widhopf II, L. Z. Rassenti, T. L. Toy, J. G. Gribben, W. G. Wierda, and T. J. Kipps
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
Blood,
October 15, 2004;
104(8):
2499 - 2504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hamano, S. Hirose, A. Ida, M. Abe, D. Zhang, S. Kodera, Y. Jiang, J. Shirai, Y. Miura, H. Nishimura, et al.
Susceptibility Alleles for Aberrant B-1 Cell Proliferation Involved in Spontaneously Occurring B-Cell Chronic Lymphocytic Leukemia in a Model of New Zealand White Mice
Blood,
November 15, 1998;
92(10):
3772 - 3779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Bahler, J. A. Miklos, and S. H. Swerdlow
Ongoing Ig Gene Hypermutation in Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphomas
Blood,
May 1, 1997;
89(9):
3335 - 3344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
