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Characteristic karyotypic pattern in T-cell lymphoproliferative disorders
with reactive "angioimmunoblastic lymphadenopathy with dysproteinemia-type"
features
Y Kaneko, N Maseki, M Sakurai, S Takayama, K Nanba, M Kikuchi and G Frizzera
Department of Laboratory Medicine, Saitama Cancer Center, Japan.
We report the clinical, histological, immunophenotypic, and cytogenetic
findings in ten patients with T-cell lymphoproliferative disorders
demonstrating reactive "angioimmunoblastic lymphadenopathy with
dysproteinemia (AILD)-type" features. Fifteen available specimens were
diagnosed as atypical hyperplasias (four) or malignant lymphomas (11). The
latter were classified as AILD-type (five), T-zone (four),
lymphoepithelioid (one), and low-grade, unclassified lymphoma (one).
Despite the histologic differences, all these lesions shared minor nuclear
atypicalities and reactive AILD-type features such as prominent
vascularity, plasma cells, eosinophils, macrophages, and residual germinal
centers. All lesions were immunophenotyped as predominantly T cell. The
chromosome pattern was characterized by the frequent presence of
karyotypically unrelated abnormal clones and/or cells with nonclonal
chromosome abnormalities, a large population of normal mitotic cells, and a
high incidence of trisomies 3 and 5. Sequential cytogenetic and histologic
studies in five patients revealed that atypical hyperplasia and lymphoma
with AILD-type features shared the same cytogenetic characteristics, ie, an
unstable coexistence of normal mitotic cells and small-clonal and/or
nonclonal abnormal cells, and that histologic transformation from low-grade
lymphoma to immunoblastic lymphoma was accompanied by a selective
proliferation of abnormal clonal cells. The AILD-type histology and the
characteristic karyotypic pattern may be the expression of a specific
pathogenesis and may warrant the separation of these neoplasias from other
peripheral T-cell lymphomas.
Volume 72,
Issue 2,
pp. 413-421,
08/01/1988
Copyright © 1988 by The American Society of Hematology
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