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H Wakui, H Imai, R Kobayashi, H Itoh, T Notoya, K Yoshida, Y Nakamoto and AB Miura
Third Department of Internal Medicine, Akita University School of Medicine,
Japan.
We observed the presence of a new autoantibody, anti-erythrocyte protein
4.1, in a patient with autoimmune hemolytic anemia (AIHA). Western blotting
analysis revealed that IgG from the patient's plasma reacted with
erythrocyte protein 4.1. However, among other patients with hemolytic
diseases (six having AIHA and three each having either hereditary
spherocytosis, elliptocytosis, or lead poisoning) as well as among control
subjects, no antibody activity to protein 4.1 was observed. In addition to
the anti-protein 4.1 antibody, two different kinds of anti-erythrocyte
antibodies were detected by conventional serological studies in this
patient. One of them was an anti-Ena-like antibody in the eluate from the
patient's erythrocytes, while another was the anti-S-specific antibody in
the plasma. An elution study and an absorption study using S
antigen-positive erythrocytes demonstrated that the anti-protein 4.1
antibody differed from both the anti-Ena-like antibody and the anti-S
antibody. Familial analysis of the patient revealed the same antibody in
her brother, who did not have hemolytic anemia. These results demonstrate
that anti-protein 4.1 antibody is considered to be included in the spectrum
of anti-cytoskeleton autoantibodies, which have been observed in patients
having increased cell lysis as well as in healthy subjects.
This article has been cited by other articles:
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| Copyright © 1988 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
