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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hill, A. V. Articles by Clegg, J. B. Search for Related Content PubMed PubMed Citation Articles by Hill, A. V. Articles by Clegg, J. B. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Beta thalassemia in Melanesia: association with malaria and characterization of a common variant (IVS-1 nt 5 G----C) AV Hill, DK Bowden, DF O'Shaughnessy, DJ Weatherall and JB Clegg Nuffield Department of Clinical Medicine, University of Oxford, England. Data on the distribution of beta thalassemia among over 6,000 Melanesians reveals a major difference in the carrier rates between populations in the malarious coastal regions of New Guinea and those living in the historically malaria-free Highlands. The island of Maewo in Vanuatu has a particularly high incidence of beta + thalassemia associated with a single restriction enzyme haplotype. Direct cloning into a plasmid vector and sequence analysis demonstrate that the mutation is a G to C transversion at position 5 of intron 1 of the beta- globin gene. Oligonucleotide probe surveys indicate that this variant accounted for all cases of beta thalassemia studied from Maewo. It is also common in coastal Papua New Guinea where haplotype and oligonucleotide probe data suggest that the molecular basis of beta thalassmia is more heterogeneous. Volume 72, Issue 1, pp. 9-14, 07/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Alain. J. Dessein, C. Chevillard, S. Marquet, S. Henri, D. Hillaire, and H. Dessein Genetics of Parasitic Infections Drug Metab. Dispos., April 1, 2001; 29(4): 484 - 488. [Abstract] [Full Text]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020