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Thrombospondin promotes platelet aggregation
GP Tuszynski, VL Rothman, A Murphy, K Siegler and KA Knudsen
Lankenau Medical Research Center, Philadelphia, PA 19151.
Thrombospondin (TSP), isolated from human platelets, promotes aggregation
of both nonstimulated platelets and platelets stimulated with thrombin or
ADP. The TSP-promoted aggregation is specific since a monoclonal antibody
against TSP inhibits the effect of exogenously added TSP and inhibits
thrombin-induced platelet aggregation in the absence of added TSP. Several
lines of evidence suggest that TSP mediates its effect on aggregation of
nonstimulated and stimulated platelets through different platelet-surface
receptor systems. The TSP- promoted aggregation of nonstimulated platelets
was inhibited by a monoclonal antibody to platelet glycoprotein IV (GPIV),
but not by a monoclonal antibody to the fibrinogen receptor, GPIIb-IIIa. In
contrast, the antibody to GPIIb-IIIa totally inhibited the TSP- potentiated
aggregation of thrombin-stimulated platelets, whereas the antibody to GPIV
has no effect. Thus, these studies suggest that TSP promotes platelet
aggregation by at least two mechanisms--one dependent on and one
independent of the platelet fibrinogen receptor system.
Volume 72,
Issue 1,
pp. 109-115,
07/01/1988
Copyright © 1988 by The American Society of Hematology
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