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Independent regulation of M-CSF and G-CSF gene expression in human
monocytes
E Vellenga, A Rambaldi, TJ Ernst, D Ostapovicz and JD Griffin
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA
02115.
The macrophage and granulocyte colony-stimulating factors, M-CSF and G-
CSF, act in vitro to induce proliferation and differentiation of monocyte
and granulocyte progenitor cells, respectively. We show here that both of
these CSFs can be produced by stimulated human blood monocytes, but the
M-CSF and G-CSF genes are independently regulated. Recombinant human
interleukin-3 (IL-3) and GM-CSF primarily induce expression of the M-CSF
gene and secretion of M-CSF, whereas bacterial lipopolysaccharide primarily
induces expression of the G-CSF gene and secretion of G-CSF. These results
suggest that under different conditions of in vitro stimulation the
monocyte secretes factors that could lead selectively to either granulocyte
or monocyte production.
Volume 71,
Issue 6,
pp. 1529-1532,
06/01/1988
Copyright © 1988 by The American Society of Hematology
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