S-100 beta positive T cell leukemia
K Takahashi, Y Ohtsuki, H Sonobe, K Hayashi, S Nakamura, S Kotani, I Kubonishi, I Miyoshi, T Isobe and K Kita
Department of Pathology, Kochi Medical School, Nankoku, Japan.
We reported a peculiar case with T cell leukemia. The patient was a 34-
year-old woman showing extensive splenomegaly and marked leukemic cell
proliferation and running a rapid fatal clinical course. The leukemic cells
were morphologically ordinary lymphocytes showing suppressor/cytotoxic(s/c)
T cell phenotypes and containing S-100b protein. Southern blot analysis
revealed rearrangement of the beta chain genes of the T cell receptor (TcR)
of the leukemic cells. Because these phenotypic and morphologic features
were identical with those of S-100 beta+T lymphocytes (S-100 beta +TL) in
normal human peripheral blood, we regarded this case as S-100 beta +T cell
leukemia. We discussed clinicopathological features of S-100 beta +T cell
leukemia/lymphoma by assessing similar cases reported so far. S-100 beta +T
cell leukemia/lymphoma is a new type of s/c T lymphocytic leukemia/lymphoma
with aggressive features.
Volume 71,
Issue 5,
pp. 1299-1303,
05/01/1988
Copyright © 1988 by The American Society of Hematology
