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Bone marrow transplantation for the treatment of acute nonlymphoblastic
leukemia in children aged less than 2 years
FL Johnson, JE Sanders, M Ruggiero, RL Chard and ED Thomas
Children's Hospital and Medical Center, Seattle.
Eleven children with acute nonlymphoblastic leukemia in first remission who
were less than 2 years of age at diagnosis were treated with 120 mg/kg of
cyclophosphamide, 12-Gy fractionated total-body irradiation, and marrow
transplantation. Seven patients remain in complete remission from 3.5 to
13.8 years posttransplant, four for more than 6.75 years. The immediate
posttransplant course was relatively uncomplicated in surviving patients.
No child developed severe graft-v-host disease. The major long-term side
effect has been a slowing in growth. Although the prognosis for such
children with conventional chemotherapy remains poor, intensive cytotoxic
therapy and marrow transplantation offers an alternative therapy with a
chance for cure.
Volume 71,
Issue 5,
pp. 1277-1280,
05/01/1988
Copyright © 1988 by The American Society of Hematology
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