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Imbalances within the peripheral blood T-helper (CD4+) and T-suppressor
(CD8+) cell populations in the reconstitution phase after human bone marrow
transplantation
A Velardi, A Terenzi, S Cucciaioni, R Millo, CE Grossi, F Grignani and MF Martelli
Department of Medicine, University of Perugia, Italy.
Peripheral blood T cell subsets were evaluated in 11 patients during the
reconstitution phase after allogeneic bone marrow transplantation and
compared with 11 age-matched controls. The proportion of cells coexpressing
Leu7 and CD11b (C3bi receptor) markers was determined within the CD4+
(T-helper) and the CD8+ (T-suppressor) subsets by two- color
immunofluorescence analysis. CD4+ and CD8+ T cells reached normal or
near-normal values within the first year posttransplant. In contrast to
normal controls, however, most of the cells in both subsets coexpressed the
Leu7 and CD11b markers. T cells with such phenotype display the
morphological features of granular lymphocytes (GLs) and a functional
inability to produce interleukin 2 (IL 2). These T cell imbalances were not
related to graft v host disease (GvHD) or to clinically detectable virus
infections and may account for some defects of cellular and humoral
immunity that occur after bone marrow transplantation.
Volume 71,
Issue 5,
pp. 1196-1200,
05/01/1988
Copyright © 1988 by The American Society of Hematology
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