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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Landolfi, R. Articles by Bizzi, B. Search for Related Content PubMed PubMed Citation Articles by Landolfi, R. Articles by Bizzi, B. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Increased platelet-fibrinogen affinity in patients with myeloproliferative disorders [see comments] R Landolfi, R De Cristofaro, M Castagnola, E De Candia, G D'Onofrio, G Leone and B Bizzi Department of Hematology, Catholic University, Rome, Italy. Patients with myeloproliferative disorders (MPD) are known to have some abnormalities of platelet glycoproteins (Gp). Quantitative changes of the Gp Ib, IIb-IIIa, and/or their glucidic content have been reported. Since the Gp IIb-IIIa complex plays a major role in fibrinogen binding by activated platelets, we measured the platelet fibrinogen affinity in nine patients with polycythemia vera (PV) and one subject with chronic myeloid leukemia (CML) by the aggregometric method of Marguerie. In all patients the Kd of the platelet fibrinogen reaction was significantly decreased as compared to controls, with evidence in two cases with PV of a heterogeneity of platelet-fibrinogen receptor sites. The measurement of 125I-labeled fibrinogen-platelet binding, performed in seven patients (five PV and two CML), showed receptor populations with increased (Kd1 = 0.58 + 0.3 X 10(7) mol/L) and normal affinity (Kd2 = 5.12 + 3.1 X 10(7) mol/L). These results demonstrate a heterogeneity of platelet-fibrinogen receptors in these patients and may explain the thrombotic diathesis of MPD subjects. Volume 71, Issue 4, pp. 978-982, 04/01/1988 Copyright © 1988 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Dingli, J. P. Utz, M. J. Krowka, A. L. Oberg, and A. Tefferi Unexplained Pulmonary Hypertension in Chronic Myeloproliferative Disorders Chest, September 1, 2001; 120(3): 801 - 808. [Abstract] [Full Text] [PDF]

	Copyright © 1988 by American Society of Hematology         Online ISSN: 1528-0020