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The bcl-2 gene is rearranged in many diffuse B-cell lymphomas
AC Aisenberg, BM Wilkes and JO Jacobson
Department of Medicine, Massachusetts General Hospital, Boston 02114.
Southern blotting was used to detect rearrangement of the bcl-2 gene in 104
cases of non-Hodgkin's lymphoma subclassified by the Working Formulation,
24 cases of B cell chronic lymphocytic leukemia (B-CLL) and 14 cases of T
cell malignancy. Earlier workers reported rearrangement of this gene
(located on chromosome 18) in a major fraction of follicular lymphomas,
lymphomas in which a 14;18 chromosome translocation is frequently observed.
In the present study, bcl-2 was rearranged in 30% (11 of 37) of follicular
lymphomas and 19% (11 of 58) of diffuse lymphomas of follicle center cell
lineage. In 18 of 19 samples studied, the rearranged bcl-2 fragment also
hybridized with a probe for the joining region of the immunoglobulin heavy
chain gene located on chromosome 14, indicating a 14;18 translocation. In
lymphomas not derived from follicle center cells, ie, diffuse lymphomas of
small B lymphocytes, B-CLL and T cell neoplasms, the bcl-2 gene was always
in germline configuration. The frequent rearrangement of bcl-2 in a variety
of B cell lymphomas of diffuse morphology (small cleaved cell, large cell,
small noncleaved cell and immunoblastic) is noteworthy.
Volume 71,
Issue 4,
pp. 969-972,
04/01/1988
Copyright © 1988 by The American Society of Hematology
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