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M Amiot, H Dastot, M Schmid, A Bernard and L Boumsell
We looked at the surface expression of the three distinct human thymic cell
surface differentiation antigens, CD1a, CD1b, and CD1c, that presently
define the first cluster of differentiation (CD) on the cells from 34
patients with acute T cell malignancies. We also studied the expression of
other T cell-restricted molecules, including the T cell receptors, on these
cells. Our results confirm the extensive phenotypic heterogeneity of the
cells from acute T cell malignancies, which contrast with the more limited
phenotypic diversity of subacute or chronic T cell malignancies. Our study
of normal children and fetal thymus cells shows that the extensive
phenotypic heterogeneity of the malignant cells reflects the heterogeneity
of the thymic subpopulations and shows that most of the phenotypes observed
on malignant T cells have a normal counterpart, particularly in the fetal
thymus. Moreover, we demonstrate that the CD1a molecules, which can form
three different types of noncovalent intermolecular complexes on the
surface of normal thymus cells, do not form any noncovalent intermolecular
complexes on the surface of leukemic cells. We also show that CD1a
molecules can form covalent intermolecular complexes with CD8 molecules on
some but not all malignant cells.
This article has been cited by other articles:
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| Copyright © 1987 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
