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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WRIGHT, J. C. Articles by HJELT, I. Search for Related Content PubMed PubMed Citation Articles by WRIGHT, J. C. Articles by HJELT, I. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1952, Vol. 7, No. 7, pp. 743-748. © 1952 American Society of Hematology, Inc. The Effect of a Folic Acid Antagonist, A-Methopterin, on the Level of the Circulating Eosinophils in Humans JANE C. WRIGHT M.D.1 and INGA HJELT 1 1 Cancer Research Foundation, Harlem Hospital, Department of Hospitals. New York, N. Y. 1. Daily eosinophil counts were obtained on a group of 10 normal individuals. This control group showed a moderate daily fluctuation in the count, with only 1 exception. 2. Daily eosinophil counts were obtained on 16 chronically ill or convalescent patients to whom A-Methopterin was administered. The eosinophil curves of 10 of these patients showed a fall of over 50 per cent at or prior to A-Methopterin toxicity. In 1 case, the count increased then decreased at toxicity to the initial level. In 3 cases definite evidence of toxicity was not demonstrable and the eosinophil level did not decrease. 3. Six patients showed a fall in their eosinophil counts before clinical evidence of A-Methopterin toxicity. Three patients showed a fall in their eosinophil counts of 75 per cent at the time of A-Methopterin toxicity. 4. Twelve of 16 cases (75 per cent), to whom A-Methopterin was administered showed definite falls in the curves of daily eosinophil counts. That cortisone and the adrenocorticotropic hormone do likewise suggests, but is not evidence, that the mechanisms are related. Submitted on February 2, 1952 Accepted on April 3, 1952 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C.-S. WRIGHT, B. SUNDHARAGIATI, J. A. BASS, and A. E. BUNNER REVIEW OF THE 1952 HEMATOLOGY LITERATURE Arch Intern Med, September 1, 1953; 92(3): 357 - 437. [Abstract] [PDF]

	Copyright © 1952 by American Society of Hematology         Online ISSN: 1528-0020