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1 Department of Pathology, University College of the West Indies, Jamaica,
W.I.
Data are presented on seven cases of thalassemia major (six of whom were
negroes) and 32 cases of thalassemia minor of whom eight had high levels
(20-26 per cent) of fetal hemoglobin. Two families with hemoglobin H disease are presented, in whom the
presence of thalassemia minor could be demonstrated. The mode of inheritance
of hemoglobin H disease is discussed. Two families with an inherited double A2 fraction of hemoglobin are presented. In one of these thalassemia was also found, in the other elliptocytosis
occurred concurrently. On the basis of these findings the existence of at least five different types
of thalassemia is postulated. A study on 93 healthy students suggests a high incidence (above 3 per
cent) of thalassemia minor in the West Indies.
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