Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by FUDENBERG, H.
Right arrow Articles by DAMESHEK, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FUDENBERG, H.
Right arrow Articles by DAMESHEK, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1961, Vol. 17, No. 1, pp. 71-82.
© 1961 American Society of Hematology, Inc.

The Body Hematocrit/Venous Hematocrit Ratio and the "Splenic Reservoir"

HUGH FUDENBERG 1, MARIO BALDINI 1, JOHN P. MAHONEY 1, and WILLIAM DAMESHEK 1

1 Blood Research Laboratory of Pratt Diagnostic Clinic-New England Center Hospital and the Department of Medicine, Tufts University School at Medicine, Boston, Mass.

1. Red cell volume and plasma volume were measured by the radioactive sodium chromate and the chromic chloride method respectively in 37 patients.

2. The body hematocrit/venous hematocrit (BH/VH) ratio was found to be constant in normal subjects and in patients in whom there was neither splenomegaly nor edema. The ratio was 0.896 ± 0.039.

3. In splenectomized patients the BH/VH ratio was normal indicating that in man, in normal conditions, the spleen does not have the function of a significant blood reservoir with raised cell/plasma ratio.

4. In patients with splenomegaly the BH/VH ratio was found to be significantly increased in direct proportion to the degree of splenic enlargement, indicating an increased concentration of erythrocytes in the enlarged spleen.

5. In the presence of extravascular fluid retention caused by prolonged prednisone treatment the BH/VH ratio was lower than normal.

6. It was concluded that in patients with splenomegaly or edema measurement of either red cell volume or plasma volume alone in conjunction with the "corrected" venous hematocrit does not permit valid assessment of the non-measured parameter nor of the total blood volume.

Submitted on June 12, 1960
Accepted on August 2, 1960


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arch Intern MedHome page
D. T. KAUNG and R. E. PETERSON
"Relative Polycythemia" or "Pseudopolycythemia"
Arch Intern Med, October 1, 1962; 110(4): 456 - 460.
[Abstract] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1961 by American Society of Hematology         Online ISSN: 1528-0020