Blood, 1961, Vol. 17, No. 1, pp. 20-44.
© 1961 American Society of Hematology, Inc.
Studies in Experimental Autoimmune Disorders. I. Clinical
and Laboratory Features of Autoimmunization
(Runt Disease) in the Mouse
HERMAN OLINER 1,
ROBERT SCHWARTZ 1,
WILLIAM DAMESHEK 1, and
Lorraine Beldotti 1
1 Blood Research Laboratory, Pratt Diagnostic Clinic-New England Center
Hospital, and the Department of Medicine, Tufts University School of Medicine.
The graft vs. host reaction (runt disease) was studied in LAF1, BDF1, and
BAF1, mice. The disease was induced by the injection of parental splenic
tissue into adult recipients.
The F1 hybrid recipients developed weight loss, hair changes, dermatitis,
hypothermia and splenomegaly. The laboratory features included hemolytic
anemia with a positive antiglobulin test, leukopenia, thrombocytopenia and
abnormalities of their plasma electrophoretic patterns.
Certain similarities between runt disease and autoimmune diseases of
man were suggested, and their significance was discussed.
Submitted on July 15, 1960
Accepted on October 5, 1960
