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Blood, 1961, Vol. 17, No. 1, pp. 109-118.
© 1961 American Society of Hematology, Inc.
The In Vivo Differentiation of Human Leukocytes into
Histiocytes, Fibroblasts and Fat Cells in Subcutaneous
Diffusion Chambers
NICHOLAS L. PETRAKIS 1,
MARY DAVIS 1, and
SALVATORE P. LUCIA 1
1 Departments of Preventive Medicine and Medicine and the Cancer Research
Institute, University of California, San Francisco, Calif.
Normal human leukocytes were cultivated in millipore diffusion chambers
which had been implanted subcutaneously in autologous and homologous
subjects. The observations were made over periods of a few days to six weeks.
It was found that mature granulocytes underwent disintegration within one to
two weeks. Mononuclear leukocytes underwent differentiation into macrophages and "polyblasts" within a few days and by three weeks had assumed
the morphologic appearance characteristic of histiocytes and fibroblast-like
cells. By four to six weeks extensive fibroblastic proliferation and marked collagen formation was found. In several chambers numerous fat cells were seen.
These in vivo studies demonstrate the mesenchymal potential for differentiation possessed by circulating mononuclear leukocytes of adult blood.
Submitted on July 8, 1960
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