Blood, 1960, Vol. 16, No. 6, pp. 1770-1776.
© 1960 American Society of Hematology, Inc.
The Role of the Kidney in the Production
of the Erythropoietic Factor
JEAN-PIERRE NAETS 1
1 Donner Laboratory and Donner Pacilion, Lawrence Radiation Laboratory, University of California, Berkeley, Calif.
The role of the kidney in production of erythropoietin was investigated.
Dogs were made anemic by phlebotomy and were then subjected to bilateral
nephrectomy, ureter ligation or ureter section. Erythropoietic stimulating activity in the dog plasma was judged by measuring the incorporation of Fe59
into the red cells of starved rats. No erythropoietic activity could be found in
the dog plasma 24 and 48 hours after nephrectomy, but erythropoietic activity
was found after ligation of the ureters.
Submitted on July 19, 1960
Accepted on September 14, 1960
