Blood, 1960, Vol. 16, No. 6, pp. 1753-1761.
© 1960 American Society of Hematology, Inc.
Neutrophil Mobilization into Peritoneal Fluid
GEORGE J. FRUHMAN 1
1 Department of Anatomy, Albert Einstein College of Medicine, New York
City, N. Y.
Rats were injected intraperitoneally with various solutions, and the local
cellular responses were studied using quantitative methods. Contrary to
reports in the literature, pure saline did not evoke a local neutrophilia after
it was injected intraperitoneally. Under similar conditions, bacterial lipopolysaccharides proved to be highly effective. Trace doses were most effective; larger doses caused a marked diminution of the response. Furthermore,
a variety of nonbacterial substances were impotent when tested under
comparable conditions.
Submitted on May 18, 1960
Accepted on June 28, 1960