Blood, 1960, Vol. 16, No. 4, pp. 1447-1455.
© 1960 American Society of Hematology, Inc.
Catheptic Activity of Leukocytes in Normal and
Leukemic Subjects
J. FRAENKEL-CONBAT 1 and
W. B. CHEW 1
1 Bruce Lyon Memorial Research Laboratory, Children’s Hospital of the East
Bay, Oakland, Calif.
1. A method has been described for the determination of the catheptic
activity of leukocytes.
2. The catheptic activity of the leukocytes of normal and leukemic individuals has been investigated.
3. The leukocytes from all cases of untreated lymphatic leukemia, either
chronic or acute, show lower catheptic activity than the leukocytes from any
of the untreated myelogenous leukemias, either chronic or acute; the values
for normal cases ranged between these two classes with much overlap.
See PDF for Table
4. The lymphocyte fractions separated from the blood of normal subjects
possess essentially the same catheptic activity as the total unfractionated
leukocyte populations.
5. An attempt to isolate granulocytes from the blood of normal subjects
for separate analysis was not successful.
Submitted on February 23, 1960
Accepted on July 12, 1960
