Blood, 1960, Vol. 16, No. 4, pp. 1433-1438.
© 1960 American Society of Hematology, Inc.
Inhibitory Effect of Some Plasma Protein Fractions
When Added to Hemostatic Arterial Blood
W. O. CRUZ 1,
J. R. MAGALHAES 1, and
L. MEIS 1
1 Laboratory of Hematology, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Dog arterial and venous plasma and lymph were fractionated by Cohn
method 10 and the fractions tested for inhibitory activity when added to normal arterial blood in the dog hind leg preparation adapted for studies on
hemostasis.
Cohn fraction IV from arterial or venous plasma and from lymph was the
only fraction, at low concentrations, able to inhibit the hemostatic ability of
normal arterial plasma.
Some facts suggest that alpha-lipoproteins are the plasma constituent of
fraction IV with inhibitory effect on normal arterial blood. Biochemical
changes in blood plasma seem more important or more directly connected
with the mechanism of normal hemostasis control than the participation of
blood cellular elements.
Submitted on December 29, 1959
Accepted on July 12, 1960
