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Blood, 1960, Vol. 16, No. 1, pp. 958-967.
© 1960 American Society of Hematology, Inc.

The Application of Fluorescent Antibody Methods to the Study of Platelets

ROBERT SILBER 1, ROBERTO BENITEZ 1, WARREN C. EVELAND 1, JOSEPH H. AKEROYD 1, and CHARLES J. DUNNE 1

1 Department of Immunohematology, Division of Immunology, Walter Reed Army Institute of Research, Washington, D. C., and Bacteriology Branch, Armed Forces Institute of Pathology, Washington, D. C.

1. Through the use of fluorescent antibody technic, it is possible to detect the antigen-antibody reaction between platelets and heterospecific antiserum, but no antigen-antibody reaction between normal human platelets and sera from patients with idiopathic thrombocytopenic purpura could be demonstrated.

2. The method permits the histologic localization of platelets in splenic tissue.

3. Whereas serum proteins can be easily removed from platelets by washing, there is an intimate association with fibrinogen so that this protein is still not removed from the platelet after 10 washings in saline.

Submitted on October 14, 1959
Accepted on November 20, 1959


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