Blood, 1960, Vol. 15, No. 6, pp. 856-862.
© 1960 American Society of Hematology, Inc.
Effect of Homologous Bone Marrow-Spleen Cell
Suspension on Survival of Swine Exposed to
Radiation from a Nuclear Weapon
HARRY W. DANIELL 1 and
WILLIAM H. CROSBY 1
1 Department of Hematology, Walter Reed Army Institute of Research, Walter
Reed Army Medical Center, Washington, D. C.
1. Swine exposed to mixed gamma and neutron irradiation from a nuclear
weapon were treated by intravenous, intracardiac or intraperitoneal injection
of homologous marrow-spleen cell suspensions.
2. This therapy did not affect survival of animals receiving sublethal, intermediate or supralethal doses of irradiation. No evidence of accelerated repopulation of hematopoietic or lymphatic tissues was found in the treated animals
that died, compared with untreated animals dying at the same time. Possible
reasons for failure to demonstrate a beneficial effect on survival are discussed.
3. A new, simple method for obtaining large numbers of marrow cells from
the vertebral column of large mammals is described.
Submitted on March 20, 1959
Accepted on October 31, 1959
