Blood, 1960, Vol. 15, No. 5, pp. 758-760.
© 1960 American Society of Hematology, Inc.
Studies in Leukemia. XV. The Induction of Leukemia in
Swiss Mice with Human Leukemic Brain Extracts
STEVEN O. SCHWARTZ 1,
WILMA SPURRIER 1,
LE ROY YATES 1, and
BILL P. MADUROS 1
1 Department of Hematology, Hektoen Institute for Medical Research, Cook
County Hospital, Chicago, Ill.
1. Cell-free suspensions and filtrates were prepared from human leukemic
and nonleukemic brains and were injected into adult Swiss mice.
2. The suspensions prepared from the leukemic brains, when concentrated
by high-speed centrifugation, produce leukemia in about 15 per cent of the
inoculated mice.
3. When the same sediment is combined with heat-inactivated sediment,
the incidence of induced leukemia increases to 40 per cent; when combined
with hyaluronidase, to about 50 per cent.
