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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by PISCIOTTA, A. V. Articles by HINZ, J. E. Search for Related Content PubMed PubMed Citation Articles by PISCIOTTA, A. V. Articles by HINZ, J. E. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1960, Vol. 15, No. 5, pp. 748-757. © 1960 American Society of Hematology, Inc. Chronic Lymphocytic Leukemia, Hypogammaglobulinemia and Autoimmune Hemolytic Anemia— An Experiment of Nature ANTHONY V. PISCIOTTA , LOUIS F. JERMAIN , and JEAN E. HINZ 1. The case study is presented of a 75 year old man who had chronic lymphatic leukemia, autoimmune hemolytic anemia and hypogammaglobulinemia. The positive antiglobulin reaction with serum made from gamma globulin and the neutralization of the antiglobulin reaction with human gamma globulin demonstrated that this patient’s erythrocytes were coated with gamma globulin. 2. There was a normal survival time of I131-labeled normal human gamma globulin, suggesting defective synthesis of gamma globulin. Failure to demonstrate radioactivity on the patient’s erythrocytes when I131-labeled normal gamma globulin was given signified that normal human gamma globulin has no affinity in vivo for the patient’s red cells and that the erythrocyte-coating protein was derived from a source endogenous to the patient. 3. These relationships favor an immunologic mechanism in the development of an antiglobulin reaction in this patient. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. GREEN, S. LITWIN, R. ADLERSBERG, and I. RUBIN Hypogammaglobulinemia With Late Development of Lymphosarcoma: Case Report Arch Intern Med, December 1, 1966; 118(6): 592 - 602. [Abstract] [PDF]

	Copyright © 1960 by American Society of Hematology         Online ISSN: 1528-0020