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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by BALDINI, M. Articles by PANNACCIULLI, I. Search for Related Content PubMed PubMed Citation Articles by BALDINI, M. Articles by PANNACCIULLI, I. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1960, Vol. 15, No. 5, pp. 614-629. © 1960 American Society of Hematology, Inc. The Maturation Rate of Reticulocytes MARIO BALDINI 1 and IVO PANNACCIULLI 1 1 Instituto di Patologia Speciale Medica of the Genoa University School of Medicine (Prof. A. Fieschi, Director), Genoa, Italy. An in vitro culture technic for the study of reticulocyte maturation was described. The method gave reproducible results and proved to be of value in the comparative study of reticulocyte maturation in blood disorders. By this method it was shown that variations in the reticulocyte maturation in vitro paralleled similar variations present in vivo. The maturation of reticulocytes from patients with different types of anemia was investigated. In some anemias the in vitro maturation of reticulocytes was prolonged, not only because younger reticulocytes were present in the blood, but also because the rate at which the reticulum substance disappeared was delayed. This was particularly evident in the anemia of chronic uremia, in Cooley’s anemia and in pernicious anemia in relapse. In only occasional cases of hereditary spherocytosis and of autoimmune hemolytic anemia was the rate of reticulocyte maturation found to be moderately delayed. In patients with iron deficiency anemia or bleeding anemia it was always normal. From the above findings the following conclusions were derived: 1. The reticulocyte number in the circulating blood is the resultant of three variables: (a) the rate of output of new reticulocytes from the bone marrow; (b) the stage of maturation at which reticulocytes are delivered into the peripheral circulation; (c) the rate of disappearance of the reticulum substance. 2. The number of reticulocytes in the circulating blood cannot be indiscriminately used as a precise index of red cell production in erythrokinetics. 3. There is good reason to believe that a defect in the rate at which the reticulocytes mature in the circulating blood is an index of a similar defect in the process of erythroblastic differentiation in the bone marrow. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. J. Koury, S. T. Koury, P. Kopsombut, and M. C. Bondurant In vitro maturation of nascent reticulocytes to erythrocytes Blood, March 1, 2005; 105(5): 2168 - 2174. [Abstract] [Full Text] [PDF]

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