Blood, 1960, Vol. 15, No. 3, pp. 395-403.
© 1960 American Society of Hematology, Inc.
Some Properties of Cross Reacting Antibody
of the ABO Blood Group System
A. RICHARDSON JONES 1 and
LORRAINE KANEB 1
1 Blood Grouping Laboratory of Boston, the Children’s Medical Center, and
the Department of Pediatrics, Harvard Medical School, Boston, Mass.
An account is given of an experiment in which the use of a "blocking"
procedure has enabled the site of action of the cross reacting antibody in group
O serum to be shown to be homologous with the A and B antigens of the red
cell. In another experiment cross reacting antibody was shown to behave
asymmetrically. In both these experiments use was made of the mixed agglutination technic for directly demonstrating the adherence of two cells of differing specificity by cross reacting antibody.
The significance of the results of these experiments is discussed in the light
of observations by other workers.
Submitted on June 11, 1959
Accepted on August 1, 1959
