Blood, 1960, Vol. 15, No. 2, pp. 236-243.
© 1960 American Society of Hematology, Inc.
Neonatal Neutropenia Due to Maternal Isoimmunization
PARVIZ LALEZARI 1,
MURRAY NUSSBAUM 1,
SIDNEY GELMAN 1, and
THEODORE H. SPAET 1
1 Department of Hematology, Laboratory Division, Montefiore Hospital, New
York, N. Y., and the Department of Medicine, Seton Hall College of Medicine, Jersey City,
N. J.
A family is reported with multiple cases of neonatal neutropenia. The first
child died of severe infection, the second was asymptomatic, the third and
the fourth children had a benign course of agranulocytosis which lasted about
10 weeks and was followed by spontaneous recovery. A potent leukoagglutinin
was found in the maternal serum which agglutinated leukocytes obtained from
the father and all three available children but failed to agglutinate the
mother’s own cells. Identical leukoagglutinin was found in the last baby’s
serum; it disappeared after the baby recovered. The disorder is tentatively
named "isoimmune neonatal neutropenia" and is considered to represent a
condition analogous to erythroblastosis fetalis.
Submitted on May 4, 1959
Accepted on July 28, 1959
