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1 Departments of Anatomy, University of Washington, Seattle, Wash., University
of California, San Francisco. Calif., and the University of Bristol, England.
Tritium-labeled thymidine was given by either intraperitoneal or intravenous
injection to 13 male guinea pigs of approximately 400 Gm. weight. At times varying from 1 hour to 30 days after the administration of thymidine, thoracic duct lymph was obtained and examined for the presence of
labeled cells. After a single dose of thymidine, a steady stream of labeled lymphocytes,
ranging from 2 to 7 per cent of the total cells, enters the blood over the
period studied. The intensity of the labeling appears to diminish gradually. Labeled large and medium lymphocytes were found in the lymph during
the first hour. Labeled small lymphocytes began to appear in the fourth hour,
in small numbers, and thereafter increased, whereas the proportion of labeled
large and medium lymphocytes steadily diminished. This sequential appearance of large, medium and small lymphocytes is interpreted as indicating the pattern of development of the cell series. The labeled
small lymphocytes appearing in the lymph are considered to be newly formed
from precursor cells located in the various lymphatic tissues.
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| Copyright © 1960 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
