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Blood, 1959, Vol. 14, No. 9, pp. 1008-1014.
© 1959 American Society of Hematology, Inc.
The Incidence of Leukemia in Families of Patients
with Hypoplasia of the Marrow
SERGIO GARRIGA 1 and
WILLIAM H. CROSBY 1
1 Department of Hematology, Walter Reed Army Institute of Research, and
the Department of Medicine, The George Washington University, Washington, D. C.
The authors have reviewed the published cases of Fanconis syndrome of
hypoplasia of the bone marrow. They have tabulated the features of the
syndrome, pointing out that atrophy of the spleen is a common fault and
may reflect a generalized dystrophy of the tissues of mesenchymal origin.
Of special interest is the demonstration of a high incidence of leukemia
in the families of patients with hereditary hypoplasia of the bone marrow.
Submitted on October 14, 1958
Accepted on November 22, 1958

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