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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by ONO, S. Articles by FURTH, J. Search for Related Content PubMed PubMed Citation Articles by ONO, S. Articles by FURTH, J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1959, Vol. 14, No. 6, pp. 770-780. © 1959 American Society of Hematology, Inc. Relation of Mastocytoma to Mast Cell Leukemia, and of Heparin, Histamine and Serotonin to Mast Cells SABURO ONO 1, LENA ZOMPETTI 1, PAUL HAGEN 1, and JACOB FURTH 1 1 Children’s Cancer Research Foundation, Children’s Medical Center, Departments of Pathology and Pharmacology, Harvard Medical School, Boston, Mass. A highly functional, transplantable neoplasm of mast cells is described. It causes solitary slowly growing tumors localized at the site of graft in muscles and subcutaneous tissues. Mast cell leukemia results when isolated cells are injected intravenously. The blood of mice with mast cell leukemia produces solid mastocytomas when injected intramuscularly. These and other observations suggest the essential identity of blood and tissue mast cells and suggest that mast cells are an independent cell type with primary residence in tissues outside the hemopoietic organs. In mastocytomas, heparin, histamine and serotonin are present in great quantities. Some histamine is released and partly excreted in the urine. In the mast cell leukemias, histamine plasma levels are slightly raised and urine levels are highly elevated. Plasma heparin values may be slightly raised in mice with mast cell tumors and are greatly increased in mast cell leukemias without a hemorrhagic state. The liver histamine and heparin values appear to be related to the number of infiltrating mast cells. Submitted on August 18, 1958 Accepted on October 23, 1958 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. S. SMITH and S. TROKEL Effects of Mast-Cell Degranulation on the Choroid Arch Ophthalmol, March 1, 1966; 75(3): 390 - 394. [Abstract] [PDF]

	Copyright © 1959 by American Society of Hematology         Online ISSN: 1528-0020