Blood, 1959, Vol. 14, No. 6, pp. 737-747.
© 1959 American Society of Hematology, Inc.
Patterns of Hemopoietic Recovery in Irradiated Mice
WILLIE W. SMITH 1,
ROBERT Q. MARSTON 1,
JEROME CORNFIELD 1,
Ilo M. Alderman 1,
Ruth E. Gillespie 1, and
H. Jeanette Ruth 1
1 Radiation Branch, National Cancer Institute and Division of Research Services, National Institutes of Health, Bethesda, Md.
We have demonstrated three distinct patterns of altered hemopoietic recovery in irradiated mice:
1. That seen in mice given isologous hemopoietic cells, in which granulocytes, lymphocytes, hemoglobin and platelets all showed an early recovery
The time required for granulocyte and lymphocyte recovery was relatively
unaffected by the amount of radiation to which the host was exposed (LD1-99).
The time between injection and recovery was also relatively constant.
2. That seen in mice given rat bone marrow, in which only granulocytes
and hemoglobin showed an early increase in concentration, with lymphocytes
and platelets recovering near the control times.
3. That seen in mice given endotoxin or colchicine prior to irradiation in
which the lymphocyte recovery was variable while the granulocytes, hemoglobin and platelets compared favorably with mice given isologous bone
marrow.
Submitted on August 1, 1958
Accepted on November 22, 1958
